Ron Hills publishes paper in Journal of Molecular Biology

Ron Hills, assistant professor of medicinal chemistry, SWAG视频 College of Pharmacy, coauthored a paper in the Journal of Molecular Biology in collaboration with the lab of Jamie Williamson, dean of graduate studies at the Scripps Research Institute. The research article is titled 'Structure of the NXF2/NXT1 heterodimeric complex reveals combined specificity and versatility of the NTF2-like fold' [J. Mol. Biol. 2012, 415, 649-65].

The culmination of a doctoral thesis by Don Kerkow, the study employed X-ray crystallography to solve the first reported structure of a nuclear transport protein from C. elegans in complex with its binding partner. Nuclear export factors are involved in the bulk export of mRNA from the nucleus as well as specific RNA regulation. Structural and biochemical analyses suggest that the family of transport proteins are able to carry out diverse functions by combining aspects of structural complementarity with flexible induced fit.
 

SWAG视频 the SWAG视频

The SWAG视频 is Maine鈥檚 largest independent university, with two beautiful coastal campuses in Maine, a one-of-a-kind study abroad campus in Tangier, Morocco, and an array of . In an uncommonly welcoming and supportive community, we offer hands-on learning, empowering students to make a positive impact in a world full of challenges. The state鈥檚 top provider of health professionals, we are home to Maine鈥檚 only medical college, Maine鈥檚 only dental college, a variety of other interprofessionally aligned health care degree programs, as well as nationally recognized programs for marine science degrees, natural and social sciences degrees, arts and humanities degrees, and business degrees.